Stain different, tag FAST
The Twinkle Factory is rooted in the wish of Arnaud Gautier, Ludovic Jullien and Franck Perez, three top-notch scientists of ENS-PSL, Sorbonne University, and Institut Curie to help life science researchers accelerate their work. The Twinkle Factory thus distributes reagents for their breakthrough protein fluorescent reporters and molecular glues, FAST and splitFAST (What is it, FAST and splitFAST?), and CATCHFIRE (What is it, CATCHFIRE?).
It all started in 2019 with a three-item-long pricelist for FAST and splitFAST. Along with cofounders’ research, non-permeant fluorogens, a far-red fluorogen, a fluorescence quencher, have added to the list. As a result, sales rapidly expanded worldwide. So far, 300 research teams at universities, life sciences startups, big pharmas, CROs, have implemented FAST and splitFAST in their research. Their key words are metabolic engineering, microbiota, protein-protein interactions, synthetic biology, cell-based assays, sensors… Furthermore, they unveiled the potential of FAST in hypoxic conditions, equipping a vast array of microorganisms.
And in 2023, we have added a whole range of fluorogenic molecular glues for CATCHFIRE.
This is just the beginning! Actinometers, and many other twinkling reagents are indeed joining the pack. Stay tuned!
Our latest post
Far-red live-cell STED super-resolution microscopy with frFAST and tfPoppy
a preprint by HUN-REN and University of Szeged teams
Our earlier posts
FAST in Thermoanaerobacter kivui – continued
towards C1-based biofuels and chemicals by TU Wien
The Twinkle Factory launches tfCarmine for near-infrared
A major addition to The Twinkle Factory’s fluorogen color range at the red end
First disclosure of CATCHFIRE in neurogenesis studies
one year after the princeps paper disclosing CATCHFIRE
Secretory system of Clostridium perfringens with FAST
disclosed by Prof. S. Melville et al. in bioRxiv
Monitoring tyrosine phosphatase activity with FAST
disclosed in ChemBioChem by Amy M. Barrios team
BRET and FAST are glad to introduce BREAKFAST
disclosed in RSC Chem. Biol. by UC Irvine researchers
One more! FAST in Corynebacterium glutamicum
disclosed in Microb. Cell Fact. by KAIST researchers
Multiplex FLIM with fluorescence lifetime-modulating FAST tags
simultaneously in France and in Russia!
Switchable targeted protein degradation with the help of splitFAST
a preprint by W. Chen & H. Yang of University of Delaware
FAST in Saccharomyces cerevisiae, a routine technique!
by the University of Queensland
GPCR in dendritic spine maturation with splitFAST
by Prof. Joris De Wit of KU Leuven and team
Interferon-inducible MX1 combat against Influenza A elucidated with FAST
by Dr. McKellar of Montpellier University
Thanks to the continued support of PSL Université and Région Ile-de-France.