Nov 20, 2023 | Catchfire, The Twinkle Factory
Into chemically induced proximity tools to control protein dimerization? Want to make sure dimerization occured? Intrigued by CATCHFIRE in Nat. Methods 2023 by Arnaud Gautier of Sorbonne University and Franck Perez of Institut Curie? Just ask us! Indeed, The...
Oct 24, 2022 | FAST and splitFAST, The Twinkle Factory
FAST and splitFAST, and all variants, and related fluorogens, in this straightforward review authored by inventor Arnaud Gautier published in Acc. Chem. Res. 2022. In this Account, Arnaud Gautier navigates through the FAST journey starting from the princeps paper in...
Sep 19, 2022 | Anaerobe labeling, FAST and splitFAST, The Twinkle Factory
FAST and splitFAST of The Twinkle Factory brought to the fore at CLOSTRIDIUM XVI. Following two postponements, the international conference CLOSTRIDIUM XVI finally happened at Toulouse (France) hosted by Prof. P. Soucaille of INSA. Hence, this gathering allowed the...
Feb 21, 2022 | FAST and splitFAST, Fluorogens, The Twinkle Factory
The membrane non-permeant fluorogen TFFox-NP adds to the ever-expanding toolkit of The Twinkle Factory. Indeed, it is coming after the dark chromophore TFDarth just released, and the far-red fluorogen TFPoppy in 2020. TFFox-NP belongs to the group of membrane...
Feb 14, 2022 | FAST and splitFAST, Fluorogens, The Twinkle Factory
The quencher tfDarth adds an exciting novel feature to the ever-expanding toolkit of The Twinkle Factory. tfDarth indeed forms a very tight, non-fluorescent assembly with pFAST. pFAST is the recently disclosed promiscuous variant of the now well-known FAST tag. A...
Oct 18, 2021 | Fluorogens, The Twinkle Factory
The patent US 11,162,951 – Membrane-impermeant fluorogenic chromophores for non-permeant FAST fluorogens was just granted by the USPTO. The inventors, Arnaud Gautier, Ludovic Jullien, Chenge Li, and Franck Perez, indeed developed very special fluorogens for...
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